dev ell ope mentz

ello

just a quick note to say what’s going on at the moment…

recording-wise, i’m meant to be finishing leila, brooklyn and shanty to go on this split EP for Oxjam with Dave Miatt. unfortunately we’re doing it all on tick, and its going really frustratingly slowly.. hence the shitty demos on myspace at the moment, sorry about that. the idea is to do some more tracking of the current sessions (produced by Izaak Bullen a.k.a. The Scarlet Letter Union) very soon. we’ll see.

longer term at least we’ve got round to putting this  facebook page up which took longer to sit down and do than you might imagine.. “will people fan me?” “should it be just me editing it or should i let someone else do it?” “why am i such a massive cunt?” etc.. but we figured it was better to have these pages up and going rather than spend ages waiting for some mythical ‘jump off’ moment. so there you go.

in the summer months lots of fun happening – will be doing another bike tour like last summer, but this time it’ll be longer and (hopefully) a few bigger venues. also the legs will be shorter and planned longer in advance – this time i REALLY want loads more people to come along for the ride!

then sometime towards the end of the summer, depending on everyone’s commitments, we’re spending a few weeks at Furnace Studios – a residential studios in Bulgaria – to jam out an LP proper for an autumn release on Sotones. Also all the back catalogue is getting slowly re-issued on digital too – stay posted for that.

in the meantime, take care of each other x
joe

ps: don’t put tipex on the keys of your computer to tell black notes from white ones in gareageband.. really bad idea…

Read more: http://www.myspace.com/lonelyjoeparker/blog?page=2#ixzz152AADp7Q

Estimating the Date of Origin of An HIV-1 Circulating Recombinant Form

Virology. 2009 Apr 25;387(1):229-34. Epub 2009 Mar 9.
Tee KK, Pybus OG, Parker J, Ng KP, Kamarulzaman A, Takebe Y.

HIV is capable of frequent genetic exchange through recombination. Despite the pandemic spread of HIV-1 recombinants, their times of origin are not well understood. We investigate the epidemic history of a HIV-1 circulating recombinant form (CRF) by estimating the time of the recombination event that lead to the emergence of CRF33_01B, a recently described recombinant descended from CRF01_AE and subtype B. The gag, pol and env genes were analyzed using a combined coalescent and relaxed molecular clock model, implemented in a Bayesian Markov chain Monte Carlo framework. Using linked genealogical trees we calculated the time interval between the common ancestor of CRF33_01B and the ancestors it shares with closely related parental lineages. The recombination event that generated CRF33_01B (t(rec)) occurred sometime between 1991 and 1993, suggesting that recombination is common in the early evolutionary history of HIV-1. The proof-of-concept approach provides a new tool for the investigation of HIV molecular epidemiology and evolution.